We are pleased to share new clinical research findings on Pycnogenol®, a French maritime pine bark extract distributed by Tradepia, from a study involving postmenopausal women.
Maintaining bone health is an important concern for women after menopause. This study looked not only at markers related to bone metabolism, but also at aspects of everyday quality of life (QOL), including vitality and physical comfort.
These findings offer new insights into the potential role of Pycnogenol® in supporting women’s health from multiple perspectives.
■ Study Overview
The study involved 67 postmenopausal women with osteopenia or stable osteoporosis.
During the first three months, participants received either 200 mg of Pycnogenol® daily or a placebo. For the following three months, all participants received Pycnogenol®.
■ Key Findings
1. Daily vitality improved by 15.2%
The Pycnogenol® group showed a 15.2% increase in vitality scores, compared with a 1.2% increase in the placebo group. The difference between the two groups was statistically significant.
2. Physical pain scores improved by 18.5%
The Pycnogenol® group showed an 18.5% improvement in physical pain scores, while the placebo group experienced a 6.2% worsening. A statistically significant difference was observed between the two groups. This improvement was also maintained during the subsequent supplementation period.

3. Changes in a marker related to bone metabolism
The blood marker CTX-1, which is associated with bone resorption, decreased by approximately 10.6% from baseline in the Pycnogenol® group. However, the difference was not statistically significant compared with the placebo group.
Supporting Bone Health Through Every Stage of Women’s Lives
We invite you to consider Pycnogenol® as an ingredient for developing bone health products designed to support women through different stages of life.
For more information about Pycnogenol® and its clinical research data, please feel free to contact us.